The antagonism of benzodiazepine withdrawal effects by the selective cholecystokininB receptor antagonist CI-988.

@article{Singh1992TheAO,
  title={The antagonism of benzodiazepine withdrawal effects by the selective cholecystokininB receptor antagonist CI-988.},
  author={L. Robindro Singh and Mark J. Field and C A Vass and John L Hughes and George Woodruff},
  journal={British journal of pharmacology},
  year={1992},
  volume={105 1},
  pages={8-10}
}
The ability of a selective cholecystokininB (CCKB) receptor antagonist, CI-988, to block benzodiazepine withdrawal effects was examined in mice. The discontinuation of twice daily administration of diazepam (1 mg kg-1, i.p.) induced withdrawal anxiogenesis and a proconvulsant effect. In contrast, no such effects were seen following withdrawal from similar… CONTINUE READING