The anorectic effect of CNTF does not require action in leptin-responsive neurons.

@article{Stefater2012TheAE,
  title={The anorectic effect of CNTF does not require action in leptin-responsive neurons.},
  author={Margaret A Stefater and AlastairH. Maclennan and Namgyu Lee and Christa M. Patterson and April Haller and Joyce E. Sorrell and Martin M. Myers and Stephen Woods and Randy J Seeley},
  journal={Endocrinology},
  year={2012},
  volume={153 6},
  pages={
          2647-54
        }
}
Leptin resistance is a feature of obesity that poses a significant therapeutic challenge. Any treatment that is effective to reduce body weight in obese patients must overcome or circumvent leptin resistance, which promotes the maintenance of excess body fat in obese individuals. Ciliary neurotrophic factor (CNTF) is unique in its ability to reduce food intake and body weight in obese, leptin-resistant humans and rodents. Although attempts to use CNTF as an obesity therapy failed due to the… CONTINUE READING
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