The annealing of tRNA3Lys to human immunodeficiency virus type 1 primer binding site is critically dependent on the NCp7 zinc fingers structure.

@article{Rmy1998TheAO,
  title={The annealing of tRNA3Lys to human immunodeficiency virus type 1 primer binding site is critically dependent on the NCp7 zinc fingers structure.},
  author={Elisabeth R{\'e}my and Hugues de Rocquigny and Patrick Petitjean and Delphine M. Muriaux and V Theilleux and Jacques Paoletti and B. Roques},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 9},
  pages={4819-22}
}
The nucleocapsid protein NCp7 of the human immunodeficiency virus type 1 contains two zinc fingers of the CX2CX4HX4C type, flanked by several basic residues, and plays a major role in viral infectivity. Thus, NCp7 was shown to promote annealing of the tRNA3Lys to the primer binding site, a key step in reverse transcription. However, previous in vitro experiments were unable to clarify the role of the zinc fingers in this process, due to nucleic acid aggregation induced by the basic N- and C… CONTINUE READING

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