The animal fatty acid synthase: one gene, one polypeptide, seven enzymes

  title={The animal fatty acid synthase: one gene, one polypeptide, seven enzymes},
  author={S. Smith},
  journal={The FASEB Journal},
  pages={1248 - 1259}
  • S. Smith
  • Published 1994
  • Chemistry, Medicine
  • The FASEB Journal
  • The animal fatty acid synthase comprises two multifunctional polypeptide chains, each containing seven discrete functional domains, juxtaposed head‐to‐tail such that two separate centers for fatty acid assembly are formed at the subunit interface. The kinetics and specificities of the component enzymes are well adapted to ensure that, at each of the two centers, the iterative condensation of an acetyl moiety with successive malonyl moieties and complete reduction of the β‐keto intermediates… CONTINUE READING
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