The angiotensin II-AT1 receptor stimulates reactive oxygen species within the cell nucleus.

  title={The angiotensin II-AT1 receptor stimulates reactive oxygen species within the cell nucleus.},
  author={Karl D. Pendergrass and Tanya M Gwathmey and Ryan D. Michalek and Jason M. Grayson and Mark C. Chappell},
  journal={Biochemical and biophysical research communications},
  volume={384 2},
We and others have reported significant expression of the Ang II Type 1 receptor (AT1R) on renal nuclei; thus, the present study assessed the functional pathways and distribution of the intracellular AT1R on isolated nuclei. Ang II (1nM) stimulated DCF fluorescence, an intranuclear indicator of reactive oxygen species (ROS), while the AT1R antagonist losartan or the NADPH oxidase (NOX) inhibitor DPI abolished the increase in ROS. Dual labeling of nuclei with antibodies against nucleoporin 62… CONTINUE READING


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