The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer.

@article{Fendrich2010TheAE,
  title={The angiotensin-I-converting enzyme inhibitor enalapril and aspirin delay progression of pancreatic intraepithelial neoplasia and cancer formation in a genetically engineered mouse model of pancreatic cancer.},
  author={Volker Fendrich and N Chen and Meike Neef and Jens Waldmann and Malte Buchholz and G. Feldmann and Emily Prentice Slater and Anirban Maitra and Detlef Klaus Bartsch},
  journal={Gut},
  year={2010},
  volume={59 5},
  pages={630-7}
}
BACKGROUND AND AIMS There are no chemopreventive strategies for pancreatic cancer or its precursor lesions, pancreatic intraepithelial neoplasia (PanINs). Recent evidence suggests that aspirin and inhibitors of angiotensin-I converting enzyme (ACE inhibitors) have potential chemopreventive properties. In this study, we used a genetically engineered mouse model of pancreatic cancer to evaluate the chemopreventive potential of these drugs. METHODS Drug treatment was initiated at the age of 5… CONTINUE READING
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