The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development.

@article{Ward2002TheAA,
  title={The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development.},
  author={Nicole Ward and D Ayot Jeoffroy Dumont},
  journal={Seminars in cell & developmental biology},
  year={2002},
  volume={13 1},
  pages={
          19-27
        }
}
The expansion or remodelling of pre-existing blood vessels, known as angiogenesis, by either nascent sprouting, intercalated or intussusceptive growth is a highly regulated process. Angiogenesis is critical not only during normal embryonic vascular development, but also in the progression of several diseases, including cancer, psoriasis, and diabetes. Mouse molecular genetic experiments have shown that the angiopoietins and their receptor Tie2/Tek are indispensable for embryonic vessel… CONTINUE READING
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