The angiopoietin:Tie 2 interaction: a potential target for future therapies in human vascular disease.

  • Andrew Moss
  • Published 2013 in Cytokine & growth factor reviews

Abstract

Angiopoietin-1 and -2 are endogenous ligands for the vascular endothelial receptor tyrosine kinase Tie2. Signalling by angiopoietin-1 promotes vascular endothelial cell survival and the sprouting and reorganisation of blood vessels, as well as inhibiting activation of the vascular endothelial barrier to reduce leakage and leucocyte migration into tissues… (More)
DOI: 10.1016/j.cytogfr.2013.05.009

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