The angiogenic switch leads to a metabolic shift in human glioblastoma.

  title={The angiogenic switch leads to a metabolic shift in human glioblastoma.},
  author={Krishna M. Talasila and Gro Vatne R\osland and Hanne R Hagland and Eskil Eskilsson and Irene H Fl\ones and Sabrina Fritah and Francisco Javier Azuaje and Nadia A. Atai and Patrick N Harter and Michel Mittelbronn and Michael I. Andersen and Justin Vareecal Joseph and Jubayer Al Hossain and Laurent Vallar and Cornelis J. F. van Noorden and Simone P Niclou and F. Thorsen and Karl J Tronstad and Charalampos Tzoulis and Rolf Bjerkvig and Hrvoje Miletic},
  volume={19 3},
Background Invasion and angiogenesis are major hallmarks of glioblastoma (GBM) growth. While invasive tumor cells grow adjacent to blood vessels in normal brain tissue, tumor cells within neovascularized regions exhibit hypoxic stress and promote angiogenesis. The distinct microenvironments likely differentially affect metabolic processes within the tumor cells. Methods In the present study, we analyzed gene expression and metabolic changes in a human GBM xenograft model that displayed… CONTINUE READING
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