The angiogenic receptor KDR is widely distributed in human tissues and tumours and relocates intracellularly on phosphorylation. An immunohistochemical study.

@article{Stewart2003TheAR,
  title={The angiogenic receptor KDR is widely distributed in human tissues and tumours and relocates intracellularly on phosphorylation. An immunohistochemical study.},
  author={Matthew D. Stewart and Helen Turley and Nathan Cook and Francesco Pezzella and Geetha Pillai and Donald Ogilvie and S. A. Cartlidge and David L Paterson and Clive G Copley and Jane Kendrew and Carmen R Barnes and Adrian L. Harris and Kevin C. Gatter},
  journal={Histopathology},
  year={2003},
  volume={43 1},
  pages={33-9}
}
AIMS Angiogenesis is an important factor in tumour growth and metastasis. Vascular endothelial growth factor receptor 2 (VEGFR-2) or KDR plays a crucial role in angiogenesis. The aim of this study was to raise and characterize antibodies against phosphorylated KDR which could be used for studies on human tissues to assess KDR activation and novel inhibitors of KDR activation in clinical trials. METHODS AND RESULTS Three monoclonal antibodies and one rabbit polyclonal antiserum were produced… CONTINUE READING

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