The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin.

@article{Huang2006TheAF,
  title={The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin.},
  author={Yujie Huang and Hubing Shi and H. Zhou and X. Song and S. Yuan and Y. Luo},
  journal={Blood},
  year={2006},
  volume={107 9},
  pages={
          3564-71
        }
}
Nucleolin, originally described as a nuclear protein, was recently found to be expressed on the surface of endothelial cells during angiogenic. However, the functions of cell-surface nucleolin in angiogenic remain mysterious. Here we report that upon endothelial cells adhering to extracellular matrix components, vascular endothelial growth factor (VEGF) mobilizes nucleolin from nucleus to cell surface. Functional blockage or down-regulation of the expression of cell-surface nucleolin in… Expand
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