The anesthetics nitrous oxide and ketamine are more neurotoxic to old than to young rat brain

@article{JevtovicTodorovic2005TheAN,
  title={The anesthetics nitrous oxide and ketamine are more neurotoxic to old than to young rat brain},
  author={V. Jevtovic-Todorovic and L. B. Carter},
  journal={Neurobiology of Aging},
  year={2005},
  volume={26},
  pages={947-956}
}
Nitrous oxide (N2O) and ketamine are common general anesthetics and antagonists of N-methyl-D-aspartate (NMDA) glutamate receptors. In clinically relevant concentrations, they induce a psychotomimetic reaction in humans and pathomorphological changes in the rat brain. We have previously shown that ketamine and N2O in combination cause the neurotoxic reaction in young adult rat brain that is apparently synergistic. Ketamine and N2O are occasionally used in geriatric anesthesia since they do not… Expand
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