The anemia of chronic disorders: studies of marrow regulation and iron metabolism.

@article{Douglas1975TheAO,
  title={The anemia of chronic disorders: studies of marrow regulation and iron metabolism.},
  author={S W Douglas and John W. Adamson},
  journal={Blood},
  year={1975},
  volume={45 1},
  pages={
          55-65
        }
}
Marrow regulation and iron metabolism were evaluated in 17 patients with mild or moderate anemia associated with chronic disorders. In addition, whole blood P50 and red cell 2,3-diphosphoglycerate (DPG) levels were measured. The study group consisted of seven patients with non-hematologic malignancies, nine with infection or inflammation, and one with idiopathic hypoproliferative anemia. The mean whole blood P50 and DPG levels were elevated to 28.5 +/- 1.9 mm Hg and 7.03 +/- 0.83 mumole/ml… 

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References

SHOWING 1-10 OF 28 REFERENCES

THE DIAGNOSIS OF IRON DEFICIENCY ANEMIA.

Intraerythrocytic adaptation to anemia.

TLDR
Increases in adenosine triphosphate also occurred but, because of the smaller amount involved, had less effect on the oxygen dissociation curve and in vivo pH changes appear of considerable importance.

Bone marrow erythropoiesis in the anemia of infection, inflammation, and malignancy.

TLDR
It is suggested that another factor to consider in the anemia of malignancy is a decreased bone marrow response to erythropoietin, which is consistently diminished relative to expected levels for the degree of anemia in the infection-inflammatory group, but not in malignancies.

Characteristics of marrow production and reticulocyte maturation in normal man in response to anemia.

  • R. Hillman
  • Medicine
    The Journal of clinical investigation
  • 1969
TLDR
Erythropoiesis in normal man was studied during periods of phlebotomy-induced anemia of varying severity, and measurements of plasma iron turnover provided an excellent index of marrow production at all levels of red cell production.

The erythropoietin-hematocrit relationship in normal and polycythemic man: implications of marrow regulation.

TLDR
Studies in subjects made anemic by bleeding demonstrated an inverse relationship between hematocrit and the log of erythropoietin excretion, and patients with hypoxia-induced erythrocytosis had increased levels of urinary eries when their hematOCrit was reduced to normal levels by phlebotomy.

Erythropoietin excretion in bone marrow failure and hemolytic anemia.

  • R. Alexanian
  • Medicine
    The Journal of laboratory and clinical medicine
  • 1973
TLDR
Observations do not support the contention that increased red cell destruction in man produces an increased rate of erythropoietin production, or that increased marrow utilization produces decreased levels.

Control of marrow production by the level of iron supply.

TLDR
In normal individuals subjected to prolonged periods of phlebotomy-induced anemia, the erythroid marrow will increase production by as little as twice to as much as eight times normal, depending on the iron supply available from different iron pools.

Serum level of erythropoietin in anemias associated with chronic infection, malignancy, and primary hematopoietic disease.

TLDR
There was no correlation with the degree of anemia in patients with chronic infection or malignancy and the erythropoietin levels were significantly lower than in Patients with iron deficiency or primary hematopoietic disease and the same degree ofAnemia.

Nature of anaemia in rheumatoid arthritis. VII. Storage of iron in rheumatoid disease.

TLDR
The simple desferrioxamine test indicates that iron storage disease may be suspected if there is an increase in urinary iron excretion in excess of ten times the amount present in the urine before injecting the chelating agent (Unseld, 1964; W6hler, 1964).

Erythropoietic effect of plasma from patients with advanced cancer.

The erythropoietic effect of plasma from anemic and nonanemic patients with various cancers was determined by increase in percentage of incorporation of injected 59Fe into circulating RBC's of