The androgen receptor can promote beta-catenin nuclear translocation independently of adenomatous polyposis coli.

@article{Mulholland2002TheAR,
  title={The androgen receptor can promote beta-catenin nuclear translocation independently of adenomatous polyposis coli.},
  author={David J. Mulholland and Helen Cheng and Kim R Reid and Paul S. Rennie and Colleen C. Nelson},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 20},
  pages={17933-43}
}
We provide evidence that the androgen receptor (AR) can promote nuclear translocation of beta-catenin in LNCaP and PC3 prostate cancer cells. Using AR-expressing cells (LNCaP) and non-AR-expressing cells (PC3) we showed by time course cell fractionation that the AR can shuttle beta-catenin into the nucleus when exposed to exogenous androgen. Cells exposed to the synthetic androgen, R1881, show distinct, punctate, nuclear co-localization of the AR and beta-catenin. We further showed that the AR… CONTINUE READING

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