The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits prostate cancer cell migration through activation of the estrogen receptor beta subtype.

@article{Guerini2005TheAD,
  title={The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits prostate cancer cell migration through activation of the estrogen receptor beta subtype.},
  author={Vittoria Guerini and Daniela Sau and Eugenia Scaccianoce and Paola Rusmini and Paolo Ciana and Adriana C Maggi and Paolo G. V. Martini and Benita S Katzenellenbogen and L. Martini and Marcella Motta and Angelo Poletti},
  journal={Cancer research},
  year={2005},
  volume={65 12},
  pages={5445-53}
}
Prostate cancer growth depends, in its earlier stages, on androgens and is usually pharmacologically modulated with androgen blockade. However, androgen-ablation therapy may generate androgen-independent prostate cancer, often characterized by an increased invasiveness. We have found that the 5alpha-reduced testosterone derivative, dihydrotestosterone (the most potent natural androgen) inhibits cell migration with an androgen receptor-independent mechanism. We have shown that the… CONTINUE READING

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