The ancient regulatory-protein family of WD-repeat proteins
@article{Neer1994TheAR, title={The ancient regulatory-protein family of WD-repeat proteins}, author={Eva J. Neer and Carl J. Schmidt and Raman Nambudripad and Temple F. Smith}, journal={Nature}, year={1994}, volume={371}, pages={297-300} }
WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp (WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular functions, such as cell division, cell-fate determination, gene transcription, transmembrane signalling, mRNA modification and vesicle fusion. Here we define the common features of the repeating units, and criteria for grouping such proteins into functional subfamilies.
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