The ancient regulatory-protein family of WD-repeat proteins

@article{Neer1994TheAR,
  title={The ancient regulatory-protein family of WD-repeat proteins},
  author={Eva J. Neer and Carl J. Schmidt and Raman Nambudripad and Temple F. Smith},
  journal={Nature},
  year={1994},
  volume={371},
  pages={297-300}
}
WD proteins are made up of highly conserved repeating units usually ending with Trp-Asp (WD). They are found in all eukaryotes but not in prokaryotes. They regulate cellular functions, such as cell division, cell-fate determination, gene transcription, transmembrane signalling, mRNA modification and vesicle fusion. Here we define the common features of the repeating units, and criteria for grouping such proteins into functional subfamilies. 
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The review summarizes the vast array of functions performed by different WD40 domain containing proteins, their domain organization and functional conservation during the course of evolution.
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