The ancient and widespread nature of the ER-mitochondria encounter structure.

  title={The ancient and widespread nature of the ER-mitochondria encounter structure.},
  author={Jeremy G Wideman and Ryan M R Gawryluk and Michael W. Gray and Joel B Dacks},
  journal={Molecular biology and evolution},
  volume={30 9},
Mitochondria are the result of a billion years of integrative evolution, converting a once free-living bacterium to an organelle deeply linked to diverse cellular processes. One way in which mitochondria are integrated with nonendosymbiotically derived organelles is via endoplasmic reticulum (ER)-mitochondria contact sites. The ER membrane is physically tethered to the mitochondrial outer membrane by the ER-mitochondria encounter structure (ERMES). However, to date, ERMES has only ever been… CONTINUE READING
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