The ancestral SgrS RNA discriminates horizontally acquired Salmonella mRNAs through a single G-U wobble pair.

@article{Papenfort2012TheAS,
  title={The ancestral SgrS RNA discriminates horizontally acquired Salmonella mRNAs through a single G-U wobble pair.},
  author={Kai Papenfort and Dimitri Podkaminski and Jay C. D. Hinton and J{\"o}rg Vogel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 13},
  pages={E757-64}
}
SgrS RNA is a model for the large class of Hfq-associated small RNAs that act to posttranscriptionally regulate bacterial mRNAs. The function of SgrS is well-characterized in nonpathogenic Escherichia coli, where it was originally shown to counteract glucose-phosphate stress by acting as a repressor of the ptsG mRNA, which encodes the major glucose transporter. We have discovered additional SgrS targets in Salmonella Typhimurium, a pathogen related to E. coli that recently acquired one-quarter… CONTINUE READING