The anatomy of mood disorders—review of structural neuroimaging studies

  title={The anatomy of mood disorders—review of structural neuroimaging studies},
  author={Jair C. Soares and J John Mann},
  journal={Biological Psychiatry},
The structural neuroimaging findings in mood disorders were reviewed, to evaluate evidence for a neuroanatomic model of pathophysiology, involving the prefrontal cortex, the basal ganglia, the amygdala-hippocampus complex, thalamus, and connections among these structures. Global atrophy is not consistently found. The best replicated finding is an increased rate of white matter and periventricular hyperintensities. A smaller frontal lobe, cerebellum, caudate, and putamen appear present in… CONTINUE READING
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