The anatomy and innervation of the mammalian pineal gland

@article{Mller2002TheAA,
  title={The anatomy and innervation of the mammalian pineal gland},
  author={M. M{\o}ller and F. M. Baeres},
  journal={Cell and Tissue Research},
  year={2002},
  volume={309},
  pages={139-150}
}
Abstract. The parenchymal cells of the mammalian pineal gland are the hormone-producing pinealocytes and the interstitial cells. In addition, perivascular phagocytes are present. The phagocytes share antigenic properties with microglial and antigen-presenting cells. In certain species, the pineal gland also contains neurons and/or neuron-like peptidergic cells. The peptidergic cells might influence the pinealocyte by a paracrine secretion of the peptide. Nerve fibers innervating the mammalian… Expand
Neuropeptide Y in the Adult and Fetal Human Pineal Gland
TLDR
It is shown by use of immunohistochemistry that neuropeptide Y is present in nerve fibers of the adult human pineal gland and could be detected as early as in the pineal of four- to five-month-old fetuses. Expand
GABAergic signaling in the rat pineal gland
TLDR
Electrophysiology of isolated pinealocytes revealed that GABA and muscimol elicit strong inward chloride currents sensitive to bicuculline and picrotoxin, clear evidence for functional GABAA receptors on the surface membrane. Expand
Autonomic nerves terminating on microvessels in the pineal organs of various submammalian vertebrates.
TLDR
The perivasal terminals found in various submammalians show that a part of the pineal autonomic fibers are vasomotoric in nature, but the vasosensor function of some fibers cannot be excluded. Expand
PACAP-containing intrapineal nerve fibers originate predominantly in the trigeminal ganglion: a combined retrograde tracing- and immunohistochemical study of the rat
TLDR
The origin of PACAP-containing nerve fibers innervating the rat pineal gland is investigated by combined retrograde tracing with Fluorogold and immunohistochemistry for PACAP and the location of the tracer was investigated in the brain and the sphenopalatine, otic, and trigeminal ganglia. Expand
The expression of α-internexin and peripherin in the developing mouse pineal gland
TLDR
Some cells in the developing mouse pineal gland may differentiated into neurons and neuron-like cells expressing both α-internexin and/or peripherin only postnatally, and these cells possess dual properties of CNS and PNS neurons in nature. Expand
Demonstration of PACAP‐immunoreactive intrapineal nerve fibers in the golden hamster (Mesocricetus auratus) originating from the trigeminal ganglion
TLDR
A network of nerve fibers containing pituitary adenylate‐cyclase activating polypeptide (PACAP) was demonstrated in the pineal gland of the golden hamster, a photoperiodic species often used in pineal and circadian rhythm research. Expand
Vasopressin and oxytocin beyond the pituitary in the human brain.
  • M. Møller
  • Medicine
  • Handbook of clinical neurology
  • 2021
TLDR
The pineal gland is innervated by vasopressin- and oxytocin-containing fibers reaching the gland via the "central innervation" in the pineal stalk, which might be involve in an annual regulation of melatonin secretion. Expand
Innervation of the pineal gland in the Arctic fox (Vulpes lagopus) by nerve fibers immunoreactive to substance P and calcitonin gene-related peptide.
TLDR
The study demonstrates the presence of substance P (SP) and calcitonin gene-related peptide (CGRP) in the nerve fibers supplying the pineal gland in the Arctic fox and suggests that these peptides can regulate/modulate melatonin secretion. Expand
Pineal ribbon synapses: regulated by the gland's central innervation.
  • S. Reuss
  • Biology, Medicine
  • Neuro endocrinology letters
  • 2010
TLDR
These data provide first evidence that the central innervation of this neuroendocrine organ plays an important role in SR (up)regulation, and that this pathway is antagonistic to the sympathetic innervation. Expand
Peptidergic and Nitrergic Innervation of the Pineal Gland in the Domestic Pig: An Immunohistochemical Study
The presence and co‐localization of vasoactive intestinal polypeptide (VIP), peptide N‐terminal histidine C‐terminal isoleucine (PHI), pituitary adenylate cyclase‐activating peptide (PACAP),Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 83 REFERENCES
The chemical neuroanatomy of the mammalian pineal gland: Neuropeptides
TLDR
Indications for the presence of neuropeptide Y, substance P, somatostatin, and vasopressin in pinealopetal nerve fibres have been presented and large interspecies variations exist with regard to the peptidergic pineal innervation and its content of peptidersgic cells. Expand
Peptidergic cells in the mammalian pineal gland. Morphological indications for a paracrine regulation of the pinealocyte.
  • M. Møller
  • Biology, Medicine
  • Biology of the cell
  • 1997
TLDR
The ultrastructural morphology suggests that the opioidergic cells exert a paracrine regulation on other pinealocytes in the pineal gland of the European hamster. Expand
Trigeminal innervation of the mammalian pineal gland
  • S. Reuss
  • Medicine, Biology
  • Microscopy research and technique
  • 1999
There is evidence that the trigeminal (Gasserian) ganglia innervate the mammalian pineal gland and serve in its regulation in addition to the sympathetic and cholinergic as well as furtherExpand
Histamine-immunoreactive nerve fibers in the rat pineal gland: evidence for a histaminergic central innervation
TLDR
Results indicate that histaminergic nerve fibers, originating from the posterior hypothalamus, project to the pineal complex of the rat, and histamine must be considered a putative neurotransmitter contained in the central innervation of the Pineal gland, but its function in pineal physiology has so far not been elucidated. Expand
A cholinergic innervation of the bovine pineal gland visualized by immunohistochemical detection of choline acetyltransferase-immunoreactive nerve fibers
TLDR
The presence of a cholinergic innervation of the bovine pineal gland, together with previous demonstration of the presence of choline acetyltransferase and muscarinic receptor binding sites in the bovo pineal glands, indicates a functional influence of a ChAT-immunoreactive nervous system on the pinealocyte. Expand
Structure and innervation of the pineal gland of the rabbit, Oryctolagus cuniculus (L.)
  • H. Romijn
  • Biology, Medicine
  • Cell and Tissue Research
  • 2004
TLDR
The results obtained from lesions of both facial nerves, taken together with the results reported in the literature, led to the conclusion that the postganglionic cholinergic nerve fibres in the pineal are of parasympathetic origin. Expand
Neuropeptide Y in the mammalian pineal gland
TLDR
The results together with the available literature show that NPY is a sympathetic transmitter, and its actions in the pineal gland are, therefore, associated with the well‐documented roles of noradrenaline. Expand
Peptidergic peripheral nervous systems in the mammalian pineal gland
TLDR
Since CGRP‐, SP‐ or VIP‐immunoreactive fibers in the pineal capsule can be traced to those in the gland, and since these fibers are ensheathed by Schwann cells, it is concluded that these fibers belong to the peripheral nervous system. Expand
Innervation of the rat pineal gland by pituitary adenylate cyclase-activating polypeptide (PACAP)-immunoreactive nerve fibres
TLDR
This study is the first demonstration of a PACAP-containing innervation of the rat pineal gland and the colocalization of PACAP with calcitonin gene-related peptide in the pinealopetal nerve fibres indicates that the majority ofPACAP-immunoreactive nerve fibre might originate from the trigeminal ganglion. Expand
Indications for a central innervation of the bovine pineal gland with substance P-immunoreactive nerve fibers
TLDR
The anatomical location of the substance P-immunoreactive nerve fibers in the pineal gland and stalk strongly indicates that, in this species, substance P’s nerve fibers originate from perikarya in the brain, probably from the medial habenular nucleus. Expand
...
1
2
3
4
5
...