The anatomo-functional connectivity of language revisited New insights provided by electrostimulation and tractography

  title={The anatomo-functional connectivity of language revisited New insights provided by electrostimulation and tractography},
  author={Hugues Duffau},
  • H. Duffau
  • Published 31 December 2008
  • Psychology
  • Neuropsychologia
Does the left superior longitudinal fascicle subserve language semantics? A brain electrostimulation study
Subcortical brain mapping by direct electrical stimulation does not provide arguments for a possible role of the left SLF in language semantic processing, and the underlying white matter of the SMG, especially the SLF, is mapped in patients who underwent awake surgery for a glioma involving the left inferior parietal lobule.
Relationships between essential cortical language sites and subcortical pathways.
The results demonstrate that DT imaging of the AF may be used to predict the location of brain areas that will be eloquent by the standards of stimulation mapping, and validate and demonstrate the utility of this AF localization technique.
Beyond the arcuate fasciculus: consensus and controversy in the connectional anatomy of language.
A challenge for researchers and clinicians to establish a coherent framework within which fibre pathway connectivity can be systematically incorporated to the study of language is established.
The Use of nrTMS Data for Tractography of Language Networks
The use of truly functional nrTMS that generated language-specific stimulation points as seed points in DTI FT of language networks, instead of calculated fMRI activation clusters, enhances the spatial resolution of the resulting tractography, providing new insights in the already complex organization of the language system.
The “frontal syndrome” revisited: Lessons from electrostimulation mapping studies
Is the left uncinate fasciculus essential for language?
It is suggested that UF is not systematically essential for language, and can be explained by the fact that the “semantic ventral stream” might be constituted by at least two parallel pathways, i.
Does post-lesional subcortical plasticity exist in the human brain?
  • H. Duffau
  • Psychology, Biology
    Neuroscience Research
  • 2009
Finding Cortical Subregions Regarding the Dorsal Language Pathway Based on the Structural Connectivity
The IFJ in the PFC, which has rarely been emphasized as a language-related subregion, also had the strongest connectivity with the previously known language- related subregions among the P FC; consequently, it is proposed that these specific regions are interconnected via the SLF and AF within the Pfc, IPC, and temporal cortex as language-based circuitry.


New insights into the anatomo-functional connectivity of the semantic system: a study using cortico-subcortical electrostimulations.
Arguments are provided in favour of the existence of a main ventral subcortical pathway underlying the semantic system, within the dominant hemisphere, joining the two essential cortical epicentres of this network: the posterior and superior temporal areas, and the orbitofrontal and dorsolateral prefontal regions.
The articulatory loop: study of the subcortical connectivity by electrostimulation
This is the first report of direct tracking of the subcortical connectivity underlying the fronto-parietal articulatory loop, allowing to better understand the pathophysiology of this network and the consequences of its damage.
Perisylvian language networks of the human brain
The anatomical findings are relevant to the evolution of language, provide a framework for Lichtheim's symptom‐based neurological model of aphasia, and constrain, anatomically, contemporary connectionist accounts of language.
Intraoperative mapping of the subcortical language pathways using direct stimulations. An anatomo-functional study.
The authors successfully used intraoperative electrical stimulations to perform subcortical language pathway mapping in order to avoid postoperative definitive deficit, and correlated these functional findings with the anatomical location of the eloquent bundles detected using postoperative MRI.
The anatomy of language: contributions from functional neuroimaging
  • C. Price
  • Psychology, Biology
    Journal of anatomy
  • 2000
From functional imaging results, a new anatomically constrained model of word processing is proposed which reconciles the anatomical ambitions of the 19th Century neurologists and the cognitive finesse of the 20th Century cognitive models.
Diffusion tensor fiber tracking shows distinct corticostriatal circuits in humans
Diffusion tensor imaging–based fiber tracking showed that the posterior, anterior, and ventral compartments of the human striatum have specific connections with the cortex, and particularly the frontal lobes, the first direct demonstration of distinct corticostriatal connections in humans.
The role of dominant striatum in language: a study using intraoperative electrical stimulations
There appear to be two separate basal ganglia systems in language, one mediated by the putamen which might have a motor role, and one by the caudate whichmight have a role in cognitive control, which could have implications for surgical strategy in lesions involving the dominant striatum.
The chronoarchitecture of the cerebral cortex
  • A. BartelsS. Zeki
  • Biology
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2005
It is demonstrated that, in a single experiment, a multitude of distinct regions can be identified across the whole brain, even within the visual cortex, including areas V1, V4 and V5.