The anaplerotic node is essential for the intracellular survival of Mycobacterium tuberculosis

@inproceedings{Basu2018TheAN,
  title={The anaplerotic node is essential for the intracellular survival of Mycobacterium tuberculosis},
  author={Piyali Basu and Noor Sandhu and Apoorva Bhatt and Albel Singh and Ricardo Balhana and Irene Gobe and Nicola A. Crowhurst and Tom A. Mendum and Liang Gao and Jane Lois Ward and Michael H. Beale and Johnjoe Mcfadden and Dany J. V. Beste},
  booktitle={The Journal of biological chemistry},
  year={2018}
}
Enzymes at the phosphoenolpyruvate (PEP)-pyruvate-oxaloacetate or anaplerotic (ANA) node control the metabolic flux to glycolysis, gluconeogenesis, and anaplerosis. Here we used genetic, biochemical, and 13C isotopomer analysis to characterize the role of the enzymes at the ANA node in intracellular survival of the world's most successful bacterial pathogen, Mycobacterium tuberculosis (Mtb). We show that each of the four ANA enzymes, pyruvate carboxylase (PCA), PEP carboxykinase (PCK), malic… CONTINUE READING
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