The anaphase promoting complex is required for memory function in mice.

@article{Kuczera2011TheAP,
  title={The anaphase promoting complex is required for memory function in mice.},
  author={Tanja Kuczera and Roman M Stilling and Hung-En Hsia and Sanaz Bahari-Javan and Stefan Irniger and Kim Nasmyth and Farahnaz Sananbenesi and Andre Fischer},
  journal={Learning & memory},
  year={2011},
  volume={18 1},
  pages={49-57}
}
Learning and memory processes critically involve the orchestrated regulation of de novo protein synthesis. On the other hand it has become clear that regulated protein degradation also plays a major role in neuronal plasticity and learning behavior. One of the key pathways mediating protein degradation is proteosomal protein destruction. The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase that targets proteins for proteosomal degradation by the 26S proteasome. While the… CONTINUE READING