The anaphase-promoting complex: proteolysis in mitosis and beyond.

Abstract

Key events in mitosis such as sister chromatid separation and subsequent inactivation of cyclin-dependent kinase 1 are regulated by ubiquitin-dependent proteolysis. These events are mediated by the anaphase-promoting complex (APC), a cell cycle-regulated ubiquitin ligase that assembles multiubiquitin chains on regulatory proteins such as securin and cyclins… (More)

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Cite this paper

@article{Peters2002TheAC, title={The anaphase-promoting complex: proteolysis in mitosis and beyond.}, author={Jan-Michael Peters}, journal={Molecular cell}, year={2002}, volume={9 5}, pages={931-43} }