The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles.

@article{Zielke2008TheAC,
  title={The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles.},
  author={Norman Zielke and Silvia Querings and Carmen Rottig and Christian F Lehner and Frank Sprenger},
  journal={Genes & development},
  year={2008},
  volume={22 12},
  pages={
          1690-703
        }
}
Endoreplicating cells undergo multiple rounds of DNA replication leading to polyploidy or polyteny. Oscillation of Cyclin E (CycE)-dependent kinase activity is the main driving force in Drosophila endocycles. High levels of CycE-Cdk2 activity trigger S phase, while down-regulation of CycE-Cdk2 activity is crucial to allow licensing of replication origins. In mitotic cells relicensing in S phase is prevented by Geminin. Here we show that Geminin protein oscillates in endoreplicating salivary… CONTINUE READING

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