The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell.

@article{Kohler2002TheAO,
  title={The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell.},
  author={Stephan Kohler and Vincent Foulongne and Safia Ouahrani-Bettache and Gis{\'e}le Bourg and Jacques Teyssier and Michel Ramuz and Jean-Pierre Liautard},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 24},
  pages={15711-6}
}
The pathogen Brucella suis resides and multiplies within a phagocytic vacuole of its host cell, the macrophage. The resulting complex relationship has been investigated by the analysis of the set of genes required for virulence, which we call intramacrophagic virulome. Ten thousand two hundred and seventy-two miniTn5 mutants of B. suis constitutively expressing gfp were screened by fluorescence microscopy for lack of intracellular multiplication in human macrophages. One hundred thirty-one such… CONTINUE READING
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