The analysis of organic anion transporting polypeptide (OATP) mRNA and protein patterns in primary and metastatic liver cancer

@article{Wlcek2011TheAO,
  title={The analysis of organic anion transporting polypeptide (OATP) mRNA and protein patterns in primary and metastatic liver cancer},
  author={Katrin Wlcek and M. Svoboda and Juliane Riha and S. Zakaria and U. Olszewski and Z. Dvoř{\'a}k and F. Sellner and I. Ellinger and W. J{\"a}ger and T. Thalhammer},
  journal={Cancer Biology \& Therapy},
  year={2011},
  volume={11},
  pages={801 - 811}
}
Organic anion transporting polypeptides (OATP, SLCO genes) mediate the uptake of endobiotics and drugs. Thus, their expression levels and pattern could be of relevance for cancer therapy. This prompted us to investigate the expression of poorly characterized OATPs, namely OATP2A1, OATP3A1, OATP4A1 and OATP5A1 in hepatic cancer of different origin. First, mRNA levels of all eleven OATPs were determined in paired (cancerous and adjacent non-cancerous) specimens from 43 patients with primary liver… Expand
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TLDR
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TLDR
This review focuses on the emerging roles for selected OATPs in cancer pharmacology, including preclinical and clinical studies suggesting roles in chemotherapy disposition, the pharmacogenetics of OATs in cancer therapy, and OATP overexpression in various tumor tissues with implications for OATps as therapeutic targets. Expand
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TLDR
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TLDR
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Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy.
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TLDR
A better understanding of not only the pathophysiological roles, but also the pharmacological effects of OATPs in cancer cells should be helpful in combating human malignant tumors. Expand
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