The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor.

Abstract

The α7 nicotinic acetylcholine receptor (nAChR) is a promising drug target for a number of neurological disorders including chronic pain and inflammatory diseases. Since α7 can function as a ligand-gated ion channel, drug development initially focused on ligands that were selective activators of the α7 ion channel. However, the best α7 drugs for chronic… (More)
DOI: 10.1016/j.neuropharm.2014.12.002

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Cite this paper

@article{Papke2015TheAP, title={The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor.}, author={Roger L Papke and Deniz Bağdaş and Abhijit R. Kulkarni and Timothy M. Gould and Shakir Dekhal Alsharari and Ganesh A Thakur and Mohamad Imad Damaj}, journal={Neuropharmacology}, year={2015}, volume={91}, pages={34-42} }