The anabolic actions of growth hormone and thyroxine on protein metabolism in Snell dwarf and normal mice.

@article{Bates1988TheAA,
  title={The anabolic actions of growth hormone and thyroxine on protein metabolism in Snell dwarf and normal mice.},
  author={Peter C. Bates and Ann T. Holder},
  journal={The Journal of endocrinology},
  year={1988},
  volume={119 1},
  pages={31-41}
}
The individual effects of GH and thyroxine (T4) on protein metabolism were determined in dwarf and normal mice in vivo. The hormone deficiencies of dwarf mice (low serum concentrations of GH and T4) resulted in decreased protein synthesis rates in skeletal muscle and liver, but no difference in synthesis rates in heart. The efficiency of synthesis (g protein/g RNA per day; KRNA) was lower in all three tissues in dwarf compared with normal mice, but effects on RNA concentration were not… CONTINUE READING