The amyloid precursor protein interacts with Go heterotrimeric protein within a cell compartment specialized in signal transduction.

@article{Brouillet1999TheAP,
  title={The amyloid precursor protein interacts with Go heterotrimeric protein within a cell compartment specialized in signal transduction.},
  author={Emmanuel Brouillet and Alain Trembleau and Damien Galanaud and Michel Volovitch and Colette Bouillot and C{\'e}cile Valenza and Alain Prochiantz and Bernadette Allinquant},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 5},
  pages={1717-27}
}
The function of the beta-amyloid protein precursor (betaAPP), a transmembrane molecule involved in Alzheimer pathologies, is poorly understood. We recently reported the presence of a fraction of betaAPP in cholesterol and sphingoglycolipid-enriched microdomains (CSEM), a caveolae-like compartment specialized in signal transduction. To investigate whether betaAPP actually interferes with cell signaling, we reexamined the interaction between betaAPP and Go GTPase. In strong contrast with results… CONTINUE READING