The amyloid precursor protein and its network of interacting proteins: physiological and pathological implications

@article{Russo2005TheAP,
  title={The amyloid precursor protein and its network of interacting proteins: physiological and pathological implications},
  author={Claudio Russo and Valentina Venezia and Emanuela Repetto and Mario Nizzari and Gennaro Schettini},
  journal={Brain Research Reviews},
  year={2005},
  volume={48},
  pages={257-264}
}
The amyloid precursor protein (APP) is an ubiquitous receptor-like molecule involved in the pathogenesis of Alzheimer's disease that generates beta-amyloid peptides and causes plaque formation. APP and some of its C-terminal proteolytic fragments (CTFs) have also been shown to be in the center of a complex protein-protein network, where selective phosphorylation of APP C-terminus may regulate the interaction with cytosolic phosphotyrosine binding (PTB) domain or Src homology 2 (SH2) domain… CONTINUE READING

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