The amyloid pathology progresses in a neurotransmitter-specific manner.

@article{Bell2006TheAP,
  title={The amyloid pathology progresses in a neurotransmitter-specific manner.},
  author={Karen F. S. Bell and Adriana Ducatenzeiler and Alfredo Ribeiro-da-Silva and Karen E Duff and David A. Bennett and Augusto Claudio Cuello},
  journal={Neurobiology of aging},
  year={2006},
  volume={27 11},
  pages={1644-57}
}
Past studies using transgenic models of early-staged amyloid pathology, have suggested that the amyloid pathology progresses in a neurotransmitter-specific manner where cholinergic terminals appear most vulnerable, followed by glutamatergic terminals and finally by somewhat more resistant GABAergic terminals. To determine whether this neurotransmitter-specific progression persists at later pathological stages, presynaptic bouton densities, and the areas of occupation and localization of plaque… CONTINUE READING