The amyloid paradox: amyloid-beta-metal complexes can be neurotoxic and neuroprotective.

@article{Bishop2004TheAP,
  title={The amyloid paradox: amyloid-beta-metal complexes can be neurotoxic and neuroprotective.},
  author={Glenda M. Bishop and Stephen R. Robinson},
  journal={Brain pathology},
  year={2004},
  volume={14 4},
  pages={448-52}
}
Senile plaques in the brains of people with Alzheimer disease (AD) are primarily composed of the amyloid-beta (Abeta) peptide and contain substantially elevated levels of iron, copper and zinc. These metals bind to Abeta and have been reported to increase the toxicity of Abeta to cultured neurones. Other reports have demonstrated that Abeta can reduce the neurotoxicity of metal ions, suggesting that the interaction can, under some circumstances, be protective. To investigate these apparently… CONTINUE READING
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