The amyloid hypothesis: let sleeping dogmas lie?

  title={The amyloid hypothesis: let sleeping dogmas lie?},
  author={Glenda M. Bishop and Stephen R. Robinson},
  journal={Neurobiology of aging},
  volume={23 6},
The 'amyloid hypothesis' has guided research into Alzheimer's disease (AD) for more than a decade. A detailed review of the relevant data led us to conclude that some data, particularly those from transgenic mice, are inconsistent with the predictions of the amyloid hypothesis. Instead, most data are consistent with the notion that amyloid-beta (Abeta) peptide is neuroprotective. The majority of commentators agreed with our analysis but some were unwilling to abandon the amyloid hypothesis… CONTINUE READING

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