The amplified WWP1 gene is a potential molecular target in breast cancer.

@article{Chen2007TheAW,
  title={The amplified WWP1 gene is a potential molecular target in breast cancer.},
  author={Ceshi Chen and Zhongmei Zhou and Jeffrey S. Ross and Wei Zhou and Jin-Tang Dong},
  journal={International journal of cancer},
  year={2007},
  volume={121 1},
  pages={80-87}
}
The amplification of the q21 band of chromosome 8 (8q21) occurs in a large percentage of breast cancers. WWP1, an HECT domain-containing ubiquitin E3 ligase located in the 8q21 region, negatively regulates the TGF-beta tumor suppressor pathway. To characterize the role of WWP1 in breast cancer, we analyzed WWP1 gene dosage and expression level as well as WWP1's function. A copy number gain of WWP1 was found in 51% (18/35) of breast cancer cell lines and in 41% (17/41) of primary breast tumors… CONTINUE READING
51 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

Similar Papers

Loading similar papers…