The amphiphilic nature of saponins and their effects on artificial and biological membranes and potential consequences for red blood and cancer cells.

@article{Lorent2014TheAN,
  title={The amphiphilic nature of saponins and their effects on artificial and biological membranes and potential consequences for red blood and cancer cells.},
  author={Joseph H. Lorent and Jo{\"e}lle Quetin-Leclercq and Marie-Paule Mingeot-Leclercq},
  journal={Organic & biomolecular chemistry},
  year={2014},
  volume={12 44},
  pages={
          8803-22
        }
}
  • Joseph H. Lorent, Joëlle Quetin-Leclercq, Marie-Paule Mingeot-Leclercq
  • Published 2014
  • Chemistry, Medicine
  • Organic & biomolecular chemistry
  • Saponins, amphiphiles of natural origin with numerous biological activities, are widely used in the cosmetic and pharmaceutical industry. Some saponins exhibit relatively selective cytotoxic effects on cancer cells but the tendency of saponins to induce hemolysis limits their anticancer potential. This review focused on the effects of saponin activity on membranes and consequent implications for red blood and cancer cells. This activity seems to be strongly related to the amphiphilic character… CONTINUE READING

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