The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function.

@article{Segrest1992TheAH,
  title={The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function.},
  author={Jere P. Segrest and Martin K. Jones and H de Loof and Christie G. Brouillette and Y. V. Venkatachalapathi and Gattadahalli M. Anantharamaiah},
  journal={Journal of lipid research},
  year={1992},
  volume={33 2},
  pages={141-66}
}
Site-directed mutagenesis and other molecular biology-based techniques are now available for probing the amphipathic alpha helix structural motif in the exchangeable apolipoproteins. Here we survey the published literature on lipid-binding and functional domains in apolipoproteins A-I, A-II, A-IV, C-I, C-II, C-III, and E and compare these results with recently developed computer methods for analysis of the location and properties of amphipathic helixes. This comparison suggests that there are… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 112 references

Identifying trarisbilayer helices in amino acid sequences of membrane proteins

M D., T. A. Steitz, A. Goldman
Annu. Rm. Biophy. Biofihy.,. Chrm • 1992

Role of basic amino acid residues in the amphipathic helix: the Snorkel Hypothesis

J. P. Segrest, Y. V. Venkatachalapathi, +3 authors G. M. Anantharamaiah.
Molecular Segresl et al. The amphipathic helix in exchangeable apolipoproteins 163 • 1991

The epitopes of apolipoprotein A-I define distinct structural domains including a mobile middle region

P. Provost, H. Koa, +3 authors E. Rassart
J . Biol . Chem • 1991

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