The amphetamine-induced sensitized state as a model of schizophrenia.

  title={The amphetamine-induced sensitized state as a model of schizophrenia.},
  author={Robert E. Featherstone and Shitij Kapur and Paul N. Fletcher},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  volume={31 8},
Schizophrenia is a serious psychiatric disorder which impacts a broad range of cognitive, behavioural and emotional domains. In animals, exposure to an intermittent, escalating dose regimen of amphetamine induces a sensitized state that appears to share a number of behavioural and neurochemical similarities with schizophrenia. In humans repeated exposure to amphetamine, or other psychomotor stimulants, can induce sensitization as well as psychosis. The following paper evaluates the evidence for… CONTINUE READING
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