The amount of neurofilaments aggregated in the cell body is controlled by their increased sensitivity to trypsin-like proteases.

Abstract

Neurofilaments are synthesised and assembled in neuronal cell bodies, transported along axons and degraded at the synapse. However, in several pathological situations they aggregate in cell bodies or axons. To investigate their turnover when separated from their normal site of degradation, we used a previously described transgenic model characterised by… (More)

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