The amount and proteolytic content of vesicles shed by human cancer cell lines correlates with their in vitro invasiveness.

@article{Ginestra1998TheAA,
  title={The amount and proteolytic content of vesicles shed by human cancer cell lines correlates with their in vitro invasiveness.},
  author={Angela Ginestra and Marco La Placa and Francesca Saladino and D Cassar{\'a} and Hideki Nagase and Maria Letizia Vittorelli},
  journal={Anticancer research},
  year={1998},
  volume={18 5A},
  pages={3433-7}
}
Cancer cells are known to shed extracellular membrane vesicles both in vitro and in vivo. To analyse their possible involvement in the metastatic behaviour of tumours, we measured the Matrigel invasion capability and amounts of vesicles shed by four human tumour cell lines (8701-BC, MCF-7, MDA-MB-231 and HT-1080), and by MCF-10A, an immortalised human breast cell line. The proteolytic activity content of vesicles was analysed by gelatin and casein zymographies. While MCF-10A cells do not… CONTINUE READING

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