The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a γδ T cell population in humanized mice

@inproceedings{Tu2011TheAP,
  title={The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a γδ T cell population in humanized mice},
  author={Wenwei Tu and Jian Teddy Zheng and Yinping Liu and Sin Fun Sia and Ming Liu and Gang Qin and Iris H. Y. Ng and Zheng Xiang and Kwok-Tai Lam and Joseph Sriyal Malik Peiris and Yu-Lung Lau},
  booktitle={The Journal of experimental medicine},
  year={2011}
}
There are few antiviral drugs for treating influenza, and the emergence of antiviral resistance has further limited the available therapeutic options. Furthermore, antivirals are not invariably effective in severe influenza, such as that caused by H5N1 viruses. Thus, there is an urgent need to develop alternative therapeutic strategies. Here, we show that human Vγ9Vδ2 T cells expanded by the aminobisphosphonate pamidronate (PAM) kill influenza virus-infected cells and inhibit viral replication… CONTINUE READING
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