The amino terminus of the vaccinia virus E3 protein is necessary to inhibit the interferon response.


Vaccinia virus (VACV) encodes a multifunctional protein, E3L, that is necessary for interferon (IFN) resistance in cells in culture. Interferon resistance has been mapped to the well-characterized carboxy terminus of E3L, which contains a conserved double-stranded RNA binding domain. The amino terminus of E3L has a Z-form nucleic acid binding domain, which… (More)
DOI: 10.1128/JVI.06889-11


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