The amino terminus of Smads permits transcriptional specificity.


Smad proteins transduce transforming growth factor-beta signals from the cell surface to the nucleus, regulating a variety of physiologic processes. In the nucleus, Smads control gene expression by binding to both DNA and transcription factors. Individual Smads regulate distinct subsets of target genes. The key residues important for this specificity are… (More)


  • Presentations referencing similar topics