The amino-terminal peptide of HIV-1 glycoprotein 41 lyses human erythrocytes and CD4+ lymphocytes.

@article{Mobley1992TheAP,
  title={The amino-terminal peptide of HIV-1 glycoprotein 41 lyses human erythrocytes and CD4+ lymphocytes.},
  author={Patrick W. Mobley and Cyril C. Curtain and Alan Kirkpatrick and M Rostamkhani and Alan J. Waring and Larry M. Gordon},
  journal={Biochimica et biophysica acta},
  year={1992},
  volume={1139 4},
  pages={251-6}
}
Functional studies assessed the cytolytic activity of the amino terminal peptide (FP-I; 23 residues 519-541) of the glycoprotein 41,000 (gp41) of the Human Immunodeficiency Virus Type-1 (HIV-1). Synthetically prepared FP-I efficiently hemolyzed human red blood cells at 37 degrees C, with 40% lysis at 32 microM. Kinetic studies indicated that FP-I induced maximal hemolysis in 30 min, probably through tight binding of the peptide with the red cell membrane. The Phe-Leu-Gly-Phe-Leu-Gly (residues… CONTINUE READING