The amino terminal domain of GluR6 subtype glutamate receptor ion channels

@inproceedings{Kumar2009TheAT,
  title={The amino terminal domain of GluR6 subtype glutamate receptor ion channels},
  author={Janesh Kumar and Peter Schuck and Rongsheng Jin and Mark L Mayer},
  booktitle={Nature Structural &Molecular Biology},
  year={2009}
}
The amino-terminal domain (ATD) of glutamate receptor ion channels, which controls their selective assembly into AMPA, kainate and NMDA receptor subtypes, is also the site of action of NMDA receptor allosteric modulators. Here we report the crystal structure of the ATD from the kainate receptor GluR6. The ATD forms dimers in solution at micromolar protein concentrations and crystallizes as a dimer. Unexpectedly, each subunit adopts an intermediate extent of domain closure compared to the apo… CONTINUE READING
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