The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells.

@article{Dalo2003TheAT,
  title={The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells.},
  author={Francesco D'alo' and Lisa M Johansen and Erik A. Nelson and Hanna S. Radomska and Erica K. Evans and Pu Zhang and Claus Nerlov and Daniel G Tenen},
  journal={Blood},
  year={2003},
  volume={102 9},
  pages={3163-71}
}
The transcription factor C/EBP alpha (CCAAT/enhancer binding protein alpha) is critical for granulopoiesis. Gene disruption in mice blocks early granulocyte differentiation and disruption of C/EBP alpha function has been implicated in human acute myeloid leukemia (AML), but no systematic structure-function analysis has been undertaken to identify the mechanisms involved in C/EBP alpha-mediated granulocyte differentiation. Here we demonstrate that loss of either of 2 key regions results in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Induction of granulocytic differentiation by two pathways

P Zhang, EA Nelson, HS Radomska
Blood • 2002

Similar Papers

Loading similar papers…