The amino-terminal C/H1 domain of CREB binding protein mediates zta transcriptional activation of latent Epstein-Barr virus.

@article{Zerby1999TheAC,
  title={The amino-terminal C/H1 domain of CREB binding protein mediates zta transcriptional activation of latent Epstein-Barr virus.},
  author={D Zerby and Chunxia Chen and Ellen Poon and Dung-Fang Lee and Ramin Shiekhattar and Paul M. Lieberman},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 3},
  pages={1617-26}
}
Latent Epstein-Barr virus (EBV) is maintained as a nucleosome-covered episome that can be transcriptionally activated by overexpression of the viral immediate-early protein, Zta. We show here that reactivation of latent EBV by Zta can be significantly enhanced by coexpression of the cellular coactivators CREB binding protein (CBP) and p300. A stable complex containing both Zta and CBP could be isolated from lytically stimulated, but not latently infected RAJI nuclear extracts. Zta-mediated… CONTINUE READING

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