The amino acid region 115-119 of ammodytoxins plays an important role in neurotoxicity.

@article{Ivanovski2000TheAA,
  title={The amino acid region 115-119 of ammodytoxins plays an important role in neurotoxicity.},
  author={Gabriela Ivanovski and Alenka Copic and Igor Kri{\vz}aj and F. Gubensek and J. Pungercar},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={276 3},
  pages={1229-34}
}
Quadruple (Y115K/I116K/R118M/N119L) and double (Y115K/I116K) mutants of ammodytoxin A, a presynaptically toxic phospholipase A(2) from Vipera ammodytes ammodytes venom, were prepared and characterized. The enzymatic activity of the quadruple mutant on phosphatidylcholine micelles was threefold higher than that of AtxA, presumably due to higher phospholipid-binding affinity, whereas the activity of the double mutant was twofold lower. The substantial decrease by more than two orders of magnitude… CONTINUE READING

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