The amino acid at position 624 in the glycoprotein of SFTSV (severe fever with thrombocytopenia virus) plays a critical role in low-pH-dependent cell fusion activity.

@article{Tsuda2017TheAA,
  title={The amino acid at position 624 in the glycoprotein of SFTSV (severe fever with thrombocytopenia virus) plays a critical role in low-pH-dependent cell fusion activity.},
  author={Yoshimi Tsuda and Manabu Igarashi and Ryo Ito and Sanae Nishio and Kenta Shimizu and Kumiko Yoshimatsu and Jiro Arikawa},
  journal={Biomedical research},
  year={2017},
  volume={38 2},
  pages={89-97}
}
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a novel phlebovirus responsible for causing an emerging zoonotic disease. We previously established subclones from SFTSV strain YG1 based on differences in low-pH-dependent cell fusion activities and found two amino acid substitutions, Y328H and R624W, in the envelope glycoprotein (GP) of high… CONTINUE READING