The amiloride inhibitable Na+ conductance of rat colonic crypt cells is suppressed by forskolin

@article{Ecke1996TheAI,
  title={The amiloride inhibitable Na+ conductance of rat colonic crypt cells is suppressed by forskolin},
  author={Daniela Ecke and Markus Bleich and Rainer Greger},
  journal={Pfl{\"u}gers Archiv},
  year={1996},
  volume={431},
  pages={984-986}
}
Previously we have shown that mid crypt cells of corticoid treated rats possess an amiloride inhibitable Na+ conductance (NAC) and show an increased Cl− conductance when stimulated by prostaglandin or the second messenger CAMP. The NAC is supposed to determine the magnitude of NaCl absorption. The Cl− conductance defines the magnitude of NaCl secretion. In the present whole cell (WC) patch clamp study we have examined whether the amiloride (3 μmol/l) inhibitable NAC is downregulated when the Cl… CONTINUE READING
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Wild type CFTR but not A508 inhibits Na* channels in Xenopus oocytes

  • M Mall, A Hipper, R Greger, K Kunzelmann
  • FEBS Lett
  • 1996
3 Excerpts

A chromanol type of K* channel blocker inhibits forskolin- but not carbachol mediated CI- secretion in rat and rabbit colon

  • D Ecke, M Bleich, +8 authors R Greger
  • Cell Physiol Biochem 5:204-2t0
  • 1995
2 Excerpts

Mutations in the putative pore-forming domain of CFTR do not change anion selectivity of the cAMP activated CI" conductance

  • A Hipper, M Mail, R Greger, K Kunzelmann
  • FEBS Lett
  • 1995
1 Excerpt

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